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Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.
As a result of this regulation, 130 drugs have been withdrawn from the market, but drugs containing multicomponent dextromethorphan can be sold over the counter. [47] In its official press release, the bureau also stated that dextromethorphan is often used as a substitute for marijuana, amphetamine, and heroin by drug abusers, and its use as an ...
Alabama Code Title 20. Food, Drugs, and Cosmetics § 20-2-2 [1] only mentions dextromethorphan in relation to the fact that it is not defined as an opioid for the sake of regulation in this state. Alabama does not have any other provisions about the regulation of dextromethorphan at this time.
Dextromethorphan/bupropion has less activity as an NMDA receptor antagonist than dextromethorphan alone. [11] This is because bupropion is a potent CYP2D6 inhibitor and prevents the bioactivation of dextromethorphan into dextrorphan , a much more potent NMDA receptor antagonist and weaker serotonin reuptake inhibitor than dextromethorphan ...
Hypersensitivity to dextromethorphan; Hypersensitivity to quinine, mefloquine, quinidine, or dextromethorphan/quinidine with a history of thrombocytopenia, hepatitis, bone marrow depression or lupus-like syndrome induced by these drugs; QT interval, prolonged or congenital long QT syndrome or a history suggesting torsades de pointes
dextromethorphan HBr/quinidine sulfate (Nuedexta) Part D is responsible for covering prescription medication unless the medication cannot be self-administered , in which case it’s covered by Part B.
Dextromethorphan – An over-the-counter cough suppressant, as well as dissociative hallucinogen. Levomethorphan – A potent opioid analgesic that was never clinically developed; a prodrug of the powerful opioid agonist analgesic levorphanol (Levo-Dromoran). Racemethorphan is the racemic mixture of both of these stereoisomers! [2]
Cough medicines, especially those containing dextromethorphan and codeine, are often abused as recreational drugs. [30] [31] Abuse may result in hallucinations, loss of consciousness and death. Many cough syrups can contain acetaminophen which will cause liver damage in recreational users. [31]