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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 25 ]

  3. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [3] [14] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [15]

  5. How to preserve muscle mass on weight-loss drugs like Wegovy

    www.aol.com/preserve-muscle-mass-weight-loss...

    The development of glucagon-like peptide-1 (GLP-1) drugs, such as Wegovy and Zepbound, has ushered in a new era in weight management. While these drugs can lead to significant weight loss ...

  6. Low-molecular-weight heparin - Wikipedia

    en.wikipedia.org/wiki/Low-molecular-weight_heparin

    Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications. [1] They are used in the prevention of blood clots and, in the treatment of venous thromboembolism ( deep vein thrombosis and pulmonary embolism ), and the treatment of myocardial infarction .

  7. FDA approves Eli Lilly’s obesity medication for obstructive ...

    www.aol.com/fda-approves-eli-lilly-obesity...

    MORE: Zepbound leads to more weight loss than Wegovy, Eli Lilly says Obstructive sleep apnea isn’t just an inconvenience, it’s a serious medical condition that impairs breathing and sleep quality.

  8. AOL

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    The search engine that helps you find exactly what you're looking for. Find the most relevant information, video, images, and answers from all across the Web.

  9. Can Weight Loss Drugs Make You Boring? Doctors Explain ...

    www.aol.com/lifestyle/weight-loss-drugs-boring...

    There are positives to this effect—namely weight loss, but also potentially treating substance use and addiction, likely due to GLP-1s’ effect on the hypothalamus.