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Robert K. Naviaux (born in 1956) is an American physician-scientist who specializes in mitochondrial medicine and complex chronic disorders. He discovered the cause of Alpers syndrome, [1] [2] and was part of the team that reported the first mitochondrial DNA (mtDNA) mutation to cause genetic forms of autism. [3]
Mitochondrial replacement therapy has been used to prevent the transmission of mitochondrial diseases from mother to child; it could only be performed in clinics licensed by the UK's Human Fertilisation and Embryology Authority (HFEA), only for people individually approved by the HFEA, for whom preimplantation genetic diagnosis is unlikely to be helpful, and only with informed consent that the ...
Autism is a neurodevelopmental condition characterized by differences in reciprocal social interaction and communication as well as restricted, repetitive interests, behaviors, or activities. [3]: 60 [4] As of 2023, no therapy exists to eliminate autism within someone, let alone to a high degree of viability. Treatment is typically catered to ...
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. Mitochondria are the organelles that generate energy for the cell and are found in every cell of the human body except red blood cells. They convert the energy of food molecules into the ATP that powers most cell functions.
The amygdala, cerebellum, and many other brain regions have been implicated in autism. [15]Unlike some brain disorders which have clear molecular hallmarks that can be observed in every affected individual, such as Alzheimer's disease or Parkinson's disease, autism does not have a unifying mechanism at the molecular, cellular, or systems level.
Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) is a rare autosomal recessive mitochondrial disease. [2] It has been previously referred to as polyneuropathy, ophthalmoplegia, leukoencephalopathy, and intestinal pseudoobstruction (POLIP syndrome). [3] The disease presents in childhood, but often goes unnoticed for decades.
This fact may also hamper the potential benefits of SCNT-derived tissues and organs for therapy, as there may be an immuno-response to the non-self mtDNA after transplant. Additionally, the genes found in the mitochondria’s genome need to communicate with the cell’s genome and a failure of somatic cell nuclear reprogramming can lead to non ...
He kept a database of research and case histories, as well as conducted and sponsored research in an attempt identify the cause of autism and offer effective treatment solutions. Rimland supported Applied Behavioral Analysis (ABA), a systematic educational approach made popular by Ivar Lovaas. [ 3 ]