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The nomenclature of monoclonal antibodies is a naming scheme for assigning generic, or nonproprietary, names to monoclonal antibodies. An antibody is a protein that is produced in B cells and used by the immune system of humans and other vertebrate animals to identify a specific foreign object like a bacterium or a virus .
The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. Types of monoclonal antibodies with other structures than naturally occurring antibodies. The abbreviations in the column Type are as follows: mab: whole monoclonal antibody; Fab: fragment, antigen-binding (one arm)
Comparison of monoclonal antibodies (brown: human, blue: non-human): top row: mouse, chimeric; bottom row: humanized, chimeric/humanized, human; The substems according to the nomenclature of monoclonal antibodies are shown below each antibody. Date: 14 February 2010, 13:34 (UTC) Source: Antibody_je2.neutral.svg; General policies for monoclonal ...
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.
In contrast, the constant (C) regions only occur in a few variants, which define the antibody's class. Antibodies of different classes activate distinct effector mechanisms in response to an antigen (triggering different elements of the innate immune system). They appear at different stages of an immune response, differ in structural features ...
English: Types of monoclonal antibodies with other structures than naturally occurring antibodies. Top row: monospecific antibodies (fragment antigen-binding, F(ab') 2 fragment, Fab' fragment, single-chain variable fragment, di-scFv, single domain antibody)
This image is a derivative work of the following images: Image:MonoclonalAb.jpg licensed with PD-author 2008-07-20T06:51:51Z Optigan13 427x285 (27307 Bytes) {{Information |Description={{en|'''Monoclonal antibodies for cancer.''' ADEPT, antibody directed enzyme prodrug therapy; ADCC, antibody dependent cell-mediated cytotoxicity; CDC, complement ...
Inhibits DNA and to a lesser extent RNA synthesis, produces single and double strand breaks in DNA possibly by free radical formation. Germ cell tumours, squamous cell carcinoma, pancreatic cancer, non-Hodgkin's, pleural sclerosing and Hodgkin's lymphoma. Pulmonary toxicity, hypersensitivity, scleroderma and Raynaud's phenomenon. Bortezomib: IV, SC