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Dexmedetomidine was developed by Orion Pharma and is marketed under the names dexdor® and Precedex®; in 1999 the US Food and Drug Administration (FDA) approved it as a short-term sedative and analgesic (<24 hours) for critically ill or injured people on mechanical ventilation in the intensive care unit. The rationale for its short-term use ...
In the European Union, dexmedetomidine received a marketing authorization from the European Medicines Agency (EMA) on August 10, 2012, under the brand name of Dexdor. [30] It is indicated for sedation in the ICU for patients needing mechanical ventilation.
Minimum alveolar concentration or MAC is the concentration, often expressed as a percentage by volume, of a vapour in the alveoli of the lungs that is needed to prevent movement (motor response) in 50% of subjects in response to surgical (pain) stimulus.
They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives, like xylazine, medetomidine and dexmedetomidine. Alpha-2 blockers increase noradrenaline release.
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The dose range advised by the manufacturers is 20–40 μg/kg intravenous for moderate sedation, but this dose may need to be higher if given intramuscularly. When given intravenously, detomidine usually takes effect in 2–5 minutes, and recovery is full within 30–60 minutes.
Michelle, 60, has often sat near former President Bush, 78, at other public events in which all living presidents gather, such as funerals for high-profile U.S. politicians.
Sir Paul McCartney has big plans for 2025.. On Saturday, Dec. 21, the Beatles musician, 82, answered a series of fan questions on his website, including what his New Year's resolution is — to ...