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3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene. [5] It is one of three forms of steroid 5α-reductase . Steroid 5α-reductase (EC 1.3.99.5) catalyzes, among other reactions, the conversion of testosterone into the more potent androgen , 5α-dihydrotestosterone (DHT).
Oxandrolone is an androgen and synthetic anabolic steroid (AAS) medication to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, to aid in the development of girls with Turner syndrome, and for other indications.
Danazol is known to bind to two steroid hormone carrier proteins: sex hormone-binding globulin (SHBG), which binds androgens and estrogens; and corticosteroid-binding globulin (CBG), which binds progesterone and cortisol. [4] [5] Binding of danazol to SHBG is considered to be more important clinically. [5]
NF-κB is a critical transcription factor involved in the synthesis of many mediators (i.e., cytokines) and proteins (i.e., adhesion proteins) that promote the immune response. Inhibition of this transcription factor, therefore, blunts the capacity of the immune system to mount a response. [2]
The steroid hormones are referred to by various abbreviations in the biological literature. The purpose of this list is to give commonly used abbreviations for steroid hormones, with supporting references to the literature.
List of steroidogenesis inhibitors – steroidogenesis inhibitors, or inhibitors of steroid biosynthesis and metabolism; As well as lists of steroid esters, including: List of androgen esters – androgen esters; List of estrogen esters – estrogen esters; List of progestogen esters – progestogen esters; List of corticosteroid esters ...
A variety of synthetic steroids and sterols have also been contrived. Most are steroids, but some nonsteroidal molecules can interact with the steroid receptors because of a similarity of shape. Some synthetic steroids are weaker or stronger than the natural steroids whose receptors they activate. [8] Some examples of synthetic steroid hormones:
Testosterone enanthate is used primarily in androgen replacement therapy. [4] [15] It is the most widely used form of testosterone in androgen replacement therapy. [4]The medication is specifically approved, in the United States, for the treatment of hypogonadism in men, delayed puberty in boys, and breast cancer in women. [16]