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According to the Reader’s Digest survey, half of women agreed that “statins can be difficult to tolerate,” compared with just 36% of men. More than one third of women believe that doctors ...
Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. [4] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. [4] It is also used to decrease the risk of heart problems in those at high risk. [4] It is taken by mouth. [4]
Doctors prescribe the daily pills based on 2013 guidelines from the American Heart Association and the American College of Cardiology, which estimate risk based on a patient’s age, diabetes ...
In children, statins are effective at reducing cholesterol levels in those with familial hypercholesterolemia. [50] Their long term safety is, however, unclear. [50] [51] Some recommend that if lifestyle changes are not enough statins should be started at 8 years old. [52]
[2] [7] Of the 4,444 people enrolled in the study, 3,617 were men and 827 women, [5] 2,223 were randomly assigned a placebo and 2,221 were given 20 to 40 mg of simvastatin daily. [1] The plan was to follow the participants for a minimum of three years or until such a time as total mortality reached 440 deaths.
Statins are generally recommended for adults between the ages of 40 and 75 who have heart disease risk factors. Despite having higher risks for cardiovascular disease, fewer older adults use statins.
With median follow-up of 6 years, simvastatin+ezetimibe was found to reduce the primary outcome of CV mortality, major CV event, or nonfatal stroke (34.7% vs. 32.7%; P=0.016; NNT 50 per 7 years or NNT 350 per 1 year ). There was no reduction in all-cause or CV mortality with simvastatin+ezetimibe, though there was a reduction in MI and stroke. [6]
It is unclear precisely how statins lead to statin-associated autoimmune myopathy. [1] The disorder is positively associated with HLA-DR11 and the DRB1*11:01 allele . [ 1 ] There are likely other unidentified genetic and environmental risk factors associated with SAAM, given the prevalence of the DRB1 allele and the low incidence of ...
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