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In comparison studies, mCPP has approximately 10-fold selectivity for the human 5-HT 2C receptor over the human 5-HT 2A and 5-HT 2B receptors (K i = 3.4 nM vs. 32.1 and 28.8 nM). [11] It acts as a partial agonist of the human 5-HT 2A [ 47 ] and 5-HT 2C [ 48 ] receptors but as an antagonist of the human 5-HT 2B receptors.
Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C 4 H 10 N 2 ·2C 6 H 8 O 7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C 4 H 10 N 2 ·C 6 H 10 O 4 (containing 1 molecule each of piperazine and adipic acid).
1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP) is a designer drug of the piperazine class of chemical substances. 3C-PEP is related to meta-cholorophenylpiperazine (mCPP) and phenethylamine that can be thought of as mCPP having a phenylethyl group attached to the nitrogen atom at its 4-position.
3,4-DCPP, CAS# 57260-67-0. The positional isomer 3,4-dichlorophenylpiperazine (3,4-DCPP) is also known, and acts as both a serotonin releaser via the serotonin transporter, [8] and a β 1-adrenergic receptor blocker, [9] though with relatively low affinity at both targets.
1-Phenylpiperazine (1-PP or PP) is a simple chemical compound and drug featuring a phenyl group bound to a piperazine ring. [1] The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class. [2] It is a rigid analogue of amphetamine.
para-Chlorophenylpiperazine (pCPP) is a psychoactive drug of the phenylpiperazine class. [1] It is relatively obscure, with limited human use, and produces slightly psychedelic effects. [citation needed] It has been encountered in illicit capsules as a recreational drug similarly to other piperazines like mCPP. [1]
Substituted piperazines are a class of chemical compounds based on a piperazine core. [1] Some are used as recreational drugs and some are used in scientific research . [ 2 ]
WY-46824 is a norepinephrine-dopamine reuptake inhibitor related to venlafaxine.It was disclosed by Paige Mahaney and colleagues from Wyeth in 2008. [1] The compound was mentioned in an earlier article from 2007 but was not the main focus of that study.