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  2. Detoxification - Wikipedia

    en.wikipedia.org/wiki/Detoxification

    The liver and kidney are naturally capable of detox, as are intracellular (specifically, inner membrane of mitochondria or in the endoplasmic reticulum of cells) proteins such as CYP enzymes. In cases of kidney failure , the action of the kidneys is mimicked by dialysis ; kidney and liver transplants are also used for kidney and liver failure ...

  3. Pharmacology of ethanol - Wikipedia

    en.wikipedia.org/wiki/Pharmacology_of_ethanol

    Ethanol does not bind to plasma proteins or other biomolecules. [13] [2] [3] The rate of distribution depends on blood supply, [4] specifically the cross-sectional area of the local capillary bed and the blood flow per gram of tissue. [13] As such, ethanol rapidly affects the brain, liver, and kidneys, which have high blood flow. [2]

  4. Alcohol tolerance - Wikipedia

    en.wikipedia.org/wiki/Alcohol_tolerance

    A liver can be damaged by chronic alcohol use, leading to a buildup of fat and scar tissue. [2] The reduced ability of such a liver to metabolize or break down alcohol means that small amounts can lead to a high blood alcohol concentration (BAC) and more rapid intoxication .

  5. First pass effect - Wikipedia

    en.wikipedia.org/wiki/First_pass_effect

    [1] [2] The effect is most associated with orally administered medications, but some drugs still undergo first-pass metabolism even when delivered via an alternate route (e.g., IV, IM, etc.). [3] During this metabolism, drug is lost during the process of absorption which is generally related to the liver and gut wall. The liver is the major ...

  6. Drug metabolism - Wikipedia

    en.wikipedia.org/wiki/Drug_metabolism

    Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...

  7. Liver regeneration - Wikipedia

    en.wikipedia.org/wiki/Liver_regeneration

    Liver regeneration is the process by which the liver is able to replace damaged or lost liver tissue. The liver is the only visceral organ with the capacity to regenerate. [ 1 ] [ 2 ] The liver can regenerate after partial hepatectomy or injury due to hepatotoxic agents such as certain medications, toxins, or chemicals. [ 3 ]

  8. 9 signs your liver is in big trouble - AOL

    www.aol.com/article/lifestyle/2019/04/25/9-signs...

    If any (or all) of these signs sound familiar, it might be time to visit your doctor. The post 9 Signs Your Liver Is In Big Trouble appeared first on Reader's Digest.

  9. Ketone bodies - Wikipedia

    en.wikipedia.org/wiki/Ketone_bodies

    Ketone bodies are transported from the liver to other tissues, where acetoacetate and β-hydroxybutyrate can be reconverted to acetyl-CoA to produce reducing equivalents (NADH and FADH 2), via the citric acid cycle. Though it is the source of ketone bodies, the liver cannot use them for energy because it lacks the enzyme thiophorase (β ...

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