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Bedinvetmab, sold under the brand name Librela is a canine monoclonal antibody used for the control of pain associated with osteoarthritis in dogs. [ 3 ] [ 4 ] [ 5 ] Librela is sponsored by Zoetis. [ 5 ] [ 6 ]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
The gram (originally gramme; [1] SI unit symbol g) is a unit of mass in the International System of Units (SI) equal to one thousandth of a kilogram.. Originally defined as of 1795 as "the absolute weight of a volume of pure water equal to the cube of the hundredth part of a metre [1 cm 3], and at the temperature of melting ice", [2] the defining temperature (≈0 °C) was later changed to 4 ...
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For instance, if the ADI is based on data from humans the safety factor is usually 10 instead of 100. The ADI is usually given in mg per kg body weight. [5] The ADI is considered a safe intake level for a healthy adult of normal weight who consumes an average daily amount of the substance in question.
See Weight for detail of mass/weight distinction and conversion. Avoirdupois is a system of mass based on a pound of 16 ounces, while Troy weight is the system of mass where 12 troy ounces equals one troy pound.
Cholinesterase inhibition was observed at all dose levels tested, and a NOAEL of 0.03 mg/kg/day estimated by dividing a LOAEL of 0.3 mg/kg/day by an uncertainty factor of 10. As with the acute RfD, the chronic RfD of 3×10 −4 mg/kg/day was determined by dividing this NOAEL by the inter- and intraspecies uncertainty factors.
Potential energy with respect to gravity, close to Earth, per unit mass: gh, where g is the acceleration due to gravity (standardized as ≈9.8 m/s 2) and h is the height above the reference level (giving J/kg when g is in m/s 2 and h is in m).