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The Philippine Nurse Licensure Examination is a 500-item multiple choice exam to test basic nursing level competency which considers the objectives of the nursing curriculum, the broad areas of nursing and other related disciplines and competencies. It is held every June and December annually in various public schools throughout the Philippines.
Questions will not be repeated; however, questions based on a similar situation could be asked. [4] Each individual will take a different form of the exam. Since each question depends on how the previous question is answered, an individual can be given between 75 and 145 questions. Only 60 out of the first 75 questions on the exam will count.
In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
The drug apparent permeability (P app) is calculated by normalizing the drug flux (j) over the initial concentration of the API in the donor compartment (c 0) as: Equation 2: = / Dimensionally, the P app represents a velocity, and it is normally expressed in cm/sec. The highest is the permeability, the highest is expected to be the ...
Recognizing drug candidates with potentially suboptimal TI at the earliest possible stage helps to initiate mitigation or potentially re-deploy resources. TI is the quantitative relationship between pharmacological efficacy and toxicological safety of a drug, without considering the nature of pharmacological or toxicological endpoints themselves.
The accumulation ratio of a specific drug in humans is determined by clinical studies. According to a 2013 analysis, such studies are typically done with 10 to 20 subjects who are given one single dose followed by a washout phase of seven days , and then seven to 14 repeated doses to reach steady state conditions. Blood samples are drawn 11 ...
The ASI-5 survey contains a total of 164 items inquiring about the general background of the patients (n= 28), their conditions in the respective areas would be asked in the following according to the participants' preference on privacy recorded during the development of ASI: 1) Medical health (n= 11) 2) Employment/ support status (n= 24) 3 & 4) Drug/ alcohol use (n= 35) 5) Illegal activity ...