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Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
The drop in blood pressure seen in sepsis can cause lightheadedness and is part of the criteria for septic shock. [21] Oxidative stress is observed in septic shock, with circulating levels of copper and vitamin C being decreased. [22]
The child can contribute to the onset of sepsis through multiple factors. Mothers contribute to the risk through a variety of ways like diets during pregnancy and potential intake of foods that are contaminated, through invasive procedures like amniocentesis and cervical cerclage , or contamination of bacteria in the vaginal canal.
Septic treatment protocol and diagnostic tools have been created due to the potentially severe outcome septic shock. For example, the SIRS criteria were created as mentioned above to be extremely sensitive in suggesting which patients may have sepsis.
People with septic shock will also likely be positive for SIRS criteria. The most generally accepted treatment for these patients is early recognition of symptoms, and early administration of broad spectrum and organism specific antibiotics. [19] Signs of septic shock include: Abnormal heart rhythms, often a fast heart rate; Reduced blood pressure
Signs of septic shock include fever or hypothermia, petechia, and purpura. Lab tests might show leukocytosis or leukopenia, metabolic acidosis with high lactate, and more. [7] Anaphylactic shock is caused by an allergen and common signs include facial swelling, throat swelling, hives, wheezing, etc. [7]
In patients with sepsis, septic shock, or multiple organ dysfunction syndrome that is due to major trauma, the rs1800625 polymorphism is a functional single nucleotide polymorphism, a part of the receptor for advanced glycation end products (RAGE) transmembrane receptor gene (of the immunoglobulin superfamily) and confers host susceptibility to ...
An older method of diagnosis was based on the patient meeting at least two criteria from the systemic inflammatory ... and from septic shock as high as 80%. [10 ...