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Finnish Center for Alternative Methods (FICAM), since 2008 [115] FRANCOPA is the French platform dedicated to development, validation, and dissemination of alternative methods in animal testing. It was created on November 16, 2007. [116] The Italian Centro 3R was created in 2017. It is an interuniversity center dedicated to the promotion of the ...
Biological tests of necessity and sufficiency refer to experimental methods and techniques that seek to test or provide evidence for specific kinds of causal relationships in biological systems. A necessary cause is one without which it would be impossible for an effect to occur, while a sufficient cause is one whose presence guarantees the ...
Student's t-test, Analysis of variance, Mann–Whitney U test Repeated measures design A research design that involves multiple measures of the same variable taken on the same or matched subjects either under different conditions or over two or more time periods.
The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) coordinates U.S. federal government evaluation of new, revised, and alternative test methods. Alternative methods are methods for safety testing of chemicals and chemical products that use fewer or no animals or that minimize or prevent animal pain and ...
Colloquially called "test-tube experiments", these studies in biology, medicine, and their subdisciplines are traditionally done in test tubes, flasks, Petri dishes, etc. [6] [7] They now involve the full range of techniques used in molecular biology, such as the omics. [8]
Recombinase polymerase amplification (RPA) is a single tube, isothermal alternative to the polymerase chain reaction (PCR). [1] By adding a reverse transcriptase enzyme to an RPA reaction, it can detect RNA as well as DNA, without the need for a separate step to produce cDNA.
As an analytical biochemistry assay and a "wet lab" technique, ELISA involves detection of an analyte (i.e., the specific substance whose presence is being quantitatively or qualitatively analyzed) in a liquid sample by a method that continues to use liquid reagents during the analysis (i.e., controlled sequence of biochemical reactions that will generate a signal which can be easily ...
The history of scientific method considers changes in the methodology of scientific inquiry, not the history of science itself. The development of rules for scientific reasoning has not been straightforward; scientific method has been the subject of intense and recurring debate throughout the history of science, and eminent natural philosophers and scientists have argued for the primacy of ...