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The inner mitochondrial membrane is both an electrical insulator and chemical barrier. Sophisticated ion transporters exist to allow specific molecules to cross this barrier. There are several antiport systems embedded in the inner membrane, allowing exchange of anions between the cytosol and the mitochondrial matrix. [7]
IMMT encodes an inner mitochondrial membrane (IMM) protein in the nucleus. It is posttranslational transported to the IMM. It is posttranslational transported to the IMM. Mic60/Mitofilin (encoded by the IMMT gene) is a core subunit of the MICOS-complex, directly located next to cristae junctions (CJ).
Tim9 and Tim10 make up the group of essential small Tim proteins that assist in transport of hydrophobic precursors across the intermembrane space in mammalian cells. Both Tim9 and Tim10 form a hexamer, the Tim9-Tim10 complex, that when associated, functions as a chaperone to assist translocation of preproteins from the outer mitochondrial membrane to the translocase of the inner membrane.
Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene. [ 5 ] [ 6 ] FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space.
30059 Ensembl ENSG00000134809 ENSMUSG00000027076 UniProt P62072 P62073 RefSeq (mRNA) NM_012456 NM_013899 RefSeq (protein) NP_036588 NP_038927 Location (UCSC) Chr 11: 57.53 – 57.53 Mb Chr 2: 84.66 – 84.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial import inner membrane translocase subunit Tim10 is an enzyme that in humans is encoded by the TIMM10 gene. TIMM10 ...
In the mitochondrion, the matrix is the space within the inner membrane. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The mitochondrial matrix contains the mitochondrial DNA, ribosomes, soluble enzymes, small organic molecules, nucleotide cofactors, and inorganic ions. [1]
Then they are transported across the inner mitochondrial membrane into the matrix and converted into the acetyl CoA to enter the citric acid cycle. [7] [8] Apoptotic components released from the intermembrane space of a mitochondrion. The respiratory chain in the inner mitochondrial membrane carries out oxidative phosphorylation.
Inner mitochondrial membrane peptidase subunit 2 (IMMP2L) is an enzyme that in humans is encoded by the IMMP2L gene on chromosome 7. [ 5 ] [ 6 ] This protein catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix , across the inner membrane , into the intermembrane space .