Search results
Results from the WOW.Com Content Network
The average life expectancy for myotonic dystrophy depends on the type. The neonatal mortality rate (death that occurs within 28 days after birth) is around 18% for infants with congenital DM1. About 25% of people with congenital DM1 die before 18 months of age and 50% die before their mid-30s.
Myotonic muscular dystrophy (DM) has two variants that affect life expectancy differently. In type 2 DM , the symptoms are usually mild and start in adulthood, so a person's lifespan is not affected much.
Age at onset is between 20 and 70 years (typically onset occurs after age 40), and life expectancy is normal. The CTG repeat size is usually in the range of 50 to 150. 1 Onset for DM2 ranges from the second to the seventh decade of life, often presenting with myotonia, weakness, or cataracts.
The life expectancy for people with congenital myotonic dystrophy type one and classic (adult-onset) myotonic dystrophy type one is typically lower.
With classic DM1, life expectancy is around 48–55 years. It is around 45 years for congenital DM1. DM2 typically does not affect life expectancy. What is the age of onset for myotonic...
People with DM1 myotonic muscular dystrophy may have a reduced life expectancy if they have severe muscle weakness, cardiac defects, or were diagnosed at a younger age. People with DM1 who have milder symptoms and people with DM2 often have a normal lifespan.
Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are autosomal dominant, multisystem disorders characterized by skeletal muscle weakness and myotonia, cardiac conduction abnormalities, iridescent cataracts, and other abnormalities. The management and prognosis of patients with DM will be reviewed here.
Life expectancy is clearly reduced for patients with congenital DM1 and is likely reduced for patients with childhood DM1 and classic (adult-onset) DM1. The most common type of DM1 — the adult-onset form — begins in adolescence or young adulthood, often with weakness in the muscles of the face, neck, fingers, and ankles.
Life expectancy can vary for people with myotonic dystrophy. Many have a normal life expectancy. People with the more severe congenital form present from birth, might die at a very young age. People whose symptoms begin as a child or teenager might have a shortened life expectancy.
Life expectancy may be reduced for people with DM1. An increased risk of death may be associated with younger age of onset, more severe muscle weakness, and cardiac conduction defects. People with more mild symptoms of DM1 may have a normal lifespan. 8