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JWH-020: Naphthoylindole: 128 ± 17: 205 ± 20: CB 1 (1.6x) JWH-030: Naphthoylpyrrole: 87 ± 3: 320 ± 127: CB 1 (3.7x) JWH-031: Naphthoylpyrrole: 399 ± 109: JWH-032: Naphthoylpyrrole >10000 >10000 — JWH-033: Naphthoylpyrrole: 666 ± 77: JWH-036: Naphthoylpyrrole: 309 ± 11: JWH-042 [6] Naphthoylindole >10000: 5050 ± 192: CB 2: JWH-043 [6 ...
A report by New Jersey United for Marijuana Reform and New Jersey Policy Perspective, issued in 2016, concluded that if New Jersey legalized marijuana, it could generate about $300 million annually in sales tax revenue for the state. (The report assumed a sales tax of 25% and annual in-state marijuana sales of $1.2 billion.) [9]
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JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist [3] at both the CB 1 and CB 2 cannabinoid receptors. It is somewhat selective for the CB 1 subtype, with affinity at this subtype approximately 5× the affinity at CB 2 . [ 4 ]
Compared to THC, which is a partial agonist at CB 1 receptors, JWH-018, and many synthetic cannabinoids, are full agonists. JWH-018 may cause intense anxiety, agitation, and in rare cases, has been assumed to have been the cause of seizures and convulsions. JWH-018 and analogs of it may present serious dangers to the user when used to excess. [22]
JWH-120 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-propyl analog of JWH-122. It is a potent and selective ligand for the CB 2 receptor, but a weaker ligand for the CB 1 receptor. It has a binding affinity of K i = 6.1 ± 0.7 nM at the CB 2 subtype and 173 times selectivity over the CB 1 subtype. [1]
JWH-048 is a selective cannabinoid ligand, with a bindining affinity of K i = 0.5 ± 0.1 nM for the CB 2 subtype, and more than 22 times selectivity over the CB 1. [ 2 ] In the United States, all CB 1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-048 are Schedule I Controlled Substances .
JWH-200 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). [6] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of ...