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In particular, prostaglandins induce abdominal contractions that can cause pain and gastrointestinal symptoms. [8] [9] The use of certain types of birth control pills can prevent the symptoms of dysmenorrhea because they stop ovulation from occurring. Dysmenorrhea is associated with increased pain sensitivity and heavy menstrual bleeding. [10] [11]
Age. The risk of most causes of joint pain increases with age. This may be due to increased wear and stress on joints over time and a higher likelihood of other underlying medical conditions ...
It can also cause depression or depressive symptoms and anxiety in some individuals. [ 25 ] [ 26 ] Long-term side effects include Cushing's syndrome , steroid dementia syndrome , [ 27 ] truncal weight gain, glaucoma and cataracts , diabetes mellitus type 2 , and depression upon dose reduction or cessation. [ 28 ]
Abrupt termination of the drug commonly causes transient non-specific symptoms such as loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss. [29] [30] These symptoms can be attributed to steroid withdrawal syndrome, adrenal insufficiency, or disease relapse. [29]
A number of diseases can cause bone pain, including the following: Endocrine, such as hyperparathyroidism, osteoporosis, kidney failure. [7]Gastrointestinal or systemic, such as celiac disease and non-celiac gluten sensitivity (both often occur without obvious digestive symptoms), inflammatory bowel disease (including Crohn's disease and ulcerative colitis).
[8] [9] [2] Bending forward, stair climbing, hill climbing, and rising from a seated position can also provoke pain. Pain can increase during menstruation in women. [8] [9] [2] People with severe and disabling sacroiliac joint dysfunction can develop insomnia and depression. [10]
The pain can appear suddenly and usually subsides within hours, although it may sometimes last two or three days. [5] [unreliable medical source?] In some cases it can last up to the following cycle. In some women, the mittelschmerz is localized enough so that they can tell which of their two ovaries provided the egg in a given month.
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with pain medication and fever reducing properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis, and primary dysmenorrhoea in adolescents and adults above 12 years old. Side effects may include liver problems. [1]