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These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
Fever is also a common side effect with use of prostaglandin E 2. Administration of prostaglandin E 2 should be stopped if a person experiences side effects such as fever. [4] The insert and gel forms have been shown to have minimal gastrointestinal effects, but are more associated with increase stimulation of the uterus as well as fetal ...
The adverse effects of enclomiphene have not been extensively studied. [10] Enclomiphene is a selective estrogen receptor modulator (SERM), which is associated with an increased risk of thrombo-embolic events. [11] Enclomiphene, unlike testosterone replacement therapy, is not associated with infertility or decreased spermatogenesis. [11]
Loop diuretics are 90% bonded to proteins and are secreted into the proximal convoluted tubule through organic anion transporter 1 (OAT-1), OAT-2, and ABCC4.Loop diuretics act on the Na +-K +-2Cl − symporter (NKCC2) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption.
An unusual side effect of digoxin is a disturbance of color vision (mostly yellow and green) called xanthopsia. Vincent van Gogh's "Yellow Period" may have somehow been influenced by concurrent digitalis therapy. Other oculotoxic effects of digoxin include generalized blurry vision, as well as seeing a "halo" around each point of light.
Progesterone therapy can prevent cardiovascular disease and atherosclerosis, and raise high-density lipoprotein: The use of micronized progesterone does not affect cardiovascular risk The side effects reported in the Women's Health Initiative study were due to the synthetic nature of the hormones used
Substrate reduction therapy is FDA approved and there is at least one treatment available on the market. [10] Gene therapy aims to replace a missing protein in the body through the use of vectors, usually viral vectors. [11] In gene therapy, a gene encoding for a certain protein is inserted into a vector. [11]
Side effects of progestogens include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and changes in liver protein production among others. [1] [2] Other side effects of progestogens may include an increased risk of breast cancer, cardiovascular disease, and blood clots. [2]