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Vitamin K reactions are adverse side effects that may occur after injection with vitamin K. [1] The liver utilizes vitamin K to produce coagulation factors that help the body form blood clots which prevent excessive bleeding. [2] [3] Vitamin K injections are administered to newborns as a preventative measure to reduce the risk of hemorrhagic ...
This combination can lead to vitamin K deficiency and later onset bleeding. Vitamin K deficiency leads to the risk of blood coagulation problems due to impaired production of clotting factors II, VII, IX, X, protein C and protein S by the liver. More rarely VKDB can be caused by maternal medicines causing vitamin K deficiency in the newborn. [2]
Phytomenadione, also known as vitamin K 1 or phylloquinone, is a vitamin found in food and used as a dietary supplement. [6] [7] It is on the World Health Organization's List of Essential Medicines. [8] It is used to treat certain bleeding disorders, [7] including warfarin overdose, vitamin K deficiency, and obstructive jaundice. [7]
4-Amino-2-methyl-1-naphthol HCl salt is a vitamin K and prevents bleeding caused by vitamin K deficiency when given via intravenous or intramuscular injections at doses of about 1–3 mg. HCl salt is water-soluble and its parenteral administration requires no emulsifiers [6] [7] unlike fat-soluble phylloquinone for example, which is often in formulations with lecithin or glycocholic acid. [8]
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The prevalence of vitamin K deficiency varies by geographic region. For infants in the United States, vitamin K 1 deficiency without bleeding may occur in as many as 50% of infants younger than 5 days old, with the classic hemorrhagic disease occurring in 0.25-1.7% of infants. [2]
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
Fetal warfarin syndrome is a disorder of the embryo which occurs in a child whose mother took the medication warfarin (brand name: Coumadin) during pregnancy.Resulting abnormalities include low birth weight, slower growth, intellectual disability, deafness, small head size, and malformed bones, cartilage, and joints.