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The Hill equation reflects the occupancy of macromolecules: the fraction that is saturated or bound by the ligand. [1] [2] [nb 1] This equation is formally equivalent to the Langmuir isotherm. [3] Conversely, the Hill equation proper reflects the cellular or tissue response to the ligand: the physiological output of the system, such as muscle ...
He showed that for many drugs, the relationship between drug concentration and biological effect corresponded to a hyperbolic curve, similar to that representing the adsorption of a gas onto a metal surface [11] and fitted the Hill–Langmuir equation. [3] Clark, together with Gaddum, was the first to introduce the log concentration–effect ...
However, a series of publications by Popova and Sel'kov [2] derived the MWC rate equation for the reversible, multi-substrate, multi-product reaction. The same problem applies to the classic Hill equation which is almost always shown in an irreversible form. Hofmeyr and Cornish-Bowden first published the reversible form of the Hill equation. [1]
Sir John Henry Gaddum FRS FRSE (31 March 1900 – 30 June 1965) was an English pharmacologist who, along with Ulf von Euler, co-discovered the neuropeptide Substance P in 1931. [1] He was a founder member of the British Pharmacological Society and first editor of the British Journal of Pharmacology .
The equation for simple ligand binding to a single homogeneous receptor is [ A R ] = [ R ] t [ A ] [ A ] + K d {\displaystyle [AR]={\frac {[R]_{t}\,[A]}{[A]+K_{d}}}} [ clarification needed ] This is the Hill-Langmuir equation, which is practically the Hill equation described for the agonist binding.
The IC 50 value is converted to an absolute inhibition constant K i using the Cheng-Prusoff equation formulated by Yung-Chi Cheng and ... Online IC50 calculator (www ...
"Soup or Salad" is a webcomic series created by Tom Mike Hill. It's a slice-of-life and comedy comic centered on the mild adventures of characters Ken and Russell. The series is hosted on ...
In the introduction to Hill equations, we read "The Hill-Langmuir equation was originally formulated by Archibald Hill in 1910 to describe the sigmoidal O2 binding curve of haemoglobin." It would be nice to have a figure with this graph, so that the less-sophisticated reader can get a sense of what the sigmoidal binding is, if someone has it.