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Hand, foot and mouth disease most commonly occurs in children under the age of 10 [4] [19] and more often under the age of 5, but it can also affect adults with varying symptoms. [20] It tends to occur in outbreaks during the spring, summer, and autumn seasons. [6] This is believed to be due to heat and humidity improving spread. [22]
Signs and symptoms are classified into three groups based on the affected functions of the frontal and temporal lobes: [8] These are behavioural variant frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia. An overlap between symptoms can occur as the disease progresses and spreads through the brain regions. [14]
"There is some literature that people with thyroid issues may be more likely to have frontal temporal dementia, and we definitely know Wendy Williams has a history of thyroid problems that I think ...
The percentage of people at end of life with dementia using feeding tubes in the US has dropped from 12% in 2000 to 6% as of 2014. [246] [247] The immediate and long-term effects of modifying the thickness of fluids for swallowing difficulties in people with dementia are not well known. [248]
In cases of asymmetric spread; the initially affected side may have more severe symptoms. [6] Although most features of FOSMN reflect lower motor neuron impairment some findings have suggested upper motor neuron impairment in FOSMN. [6] Frontotemporal dementia, including the behavioral variant, is a co-morbid condition associated with FOSMN. [6]
The impact on life expectancy depends on the individual condition, [9] but is usually severe without treatment. [1] [3] It's estimated only 25–29% of people affected survive to adulthood, and only 10% to the age of 50. [1] The median life expectancy is around 9 years, and the average life expectancy is 16.3 years. [1]
The first symptoms are often mistakenly attributed to aging or stress. [34] Detailed neuropsychological testing can reveal mild cognitive difficulties up to eight years before a person fulfills the clinical criteria for diagnosis of Alzheimer's disease. [35] These early symptoms can affect the most complex activities of daily living. [36]
It is common for people to establish cardiac arrhythmias and difficulties eating food as the disease progresses. [49] Batten disease diagnosis depends on a conflation of many criteria: clinical signs and symptoms, evaluations of the eye, electroencephalograms (EEG), and brain magnetic resonance imaging (MRI) results. [ 48 ]
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