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Severe weakness of the proximal muscles (shoulders, upper arms, thighs) on both sides of the body, very high blood levels of the enzyme creatine kinase (CK) being released by broken down skeletal muscle, and persistent symptoms and CK elevation despite stopping the offending statin medication are the hallmarks of SAAM.
This means creatine kinase in blood may be elevated in a wide range of clinical conditions including the use of medication such as statins; endocrine disorders such as hypothyroidism; [18] and skeletal muscle diseases and disorders including malignant hyperthermia, [19] and neuroleptic malignant syndrome.
Other statins have a small risk of 0.44 cases per 10 000 person-years. [9] ... Very high creatine kinase levels are detected, and mortality from this condition is 89%.
Polymyositis and the associated inflammatory myopathies have an associated increased risk of cancer. [3] The features they found associated with an increased risk of cancer were older age, age greater than 45, male sex, difficulty swallowing, death of skin cells, cutaneous vasculitis, rapid onset of myositis (<4 weeks), elevated creatine kinase, higher erythrocyte sedimentation rate and higher ...
Isolated hyperCKemia is a benign [1] genetic disorder which is characterized by high levels of creatine kinase (an enzyme) in the blood, usually, levels of CK in the blood of people with this disorder are 3 to 10 times higher than average.
In rare cases, they may progress into rhabdomyolysis, a condition manifested by muscle necrosis and myoglobinuria due to heightened creatine kinase levels. [22] [23] Another consequence of taking statins is the risk of developing new-onset diabetes, which is more prominent in individuals with high TG levels and body mass index (BMI). [19]
Blood tests: lactate/pyruvate ratio may be elevated or normal, creatine kinase (CK) may be elevated or normal. [6] [2] Electrolyte panel, anion gap, glucose, vitamin D, TSH, anti-HMGCR and AChR autoantibodies to rule-out pseudometabolic myopathies. [6] [2]
12715 Ensembl ENSG00000104879 ENSMUSG00000030399 UniProt P06732 P07310 RefSeq (mRNA) NM_001824 NM_007710 RefSeq (protein) NP_001815 NP_031736 Location (UCSC) Chr 19: 45.31 – 45.32 Mb Chr 7: 19.14 – 19.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Creatine kinase, muscle also known as MCK, CKMM, M-CK, and CPK-M, is a creatine kinase that in humans is encoded by the MCK gene ...