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Severe weakness of the proximal muscles (shoulders, upper arms, thighs) on both sides of the body, very high blood levels of the enzyme creatine kinase (CK) being released by broken down skeletal muscle, and persistent symptoms and CK elevation despite stopping the offending statin medication are the hallmarks of SAAM.
Other statins have a small risk of 0.44 cases per 10 000 person-years. [9] ... Very high creatine kinase levels are detected, and mortality from this condition is 89%.
This means creatine kinase in blood may be elevated in a wide range of clinical conditions including the use of medication such as statins; endocrine disorders such as hypothyroidism; [18] and skeletal muscle diseases and disorders including malignant hyperthermia, [19] and neuroleptic malignant syndrome.
Monitoring liver enzymes and creatine kinase is especially prudent in those on high-dose statins or in those on statin/fibrate combinations, and mandatory in the case of muscle cramps or of deterioration in kidney function. [128]
Polymyositis and the associated inflammatory myopathies have an associated increased risk of cancer. [3] The features they found associated with an increased risk of cancer were older age, age greater than 45, male sex, difficulty swallowing, death of skin cells, cutaneous vasculitis, rapid onset of myositis (<4 weeks), elevated creatine kinase, higher erythrocyte sedimentation rate and higher ...
Isolated hyperCKemia is a benign [1] genetic disorder which is characterized by high levels of creatine kinase (an enzyme) in the blood, usually, levels of CK in the blood of people with this disorder are 3 to 10 times higher than average.
Cumulative toxicity is a high probability in this clinical setting, and a severe neuromyopathy may result. The presentation includes a progressive onset of proximal weakness, elevated creatine kinase, and sensorimotor polyneuropathy. Colchicine toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs. [26]
12715 Ensembl ENSG00000104879 ENSMUSG00000030399 UniProt P06732 P07310 RefSeq (mRNA) NM_001824 NM_007710 RefSeq (protein) NP_001815 NP_031736 Location (UCSC) Chr 19: 45.31 – 45.32 Mb Chr 7: 19.14 – 19.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Creatine kinase, muscle also known as MCK, CKMM, M-CK, and CPK-M, is a creatine kinase that in humans is encoded by the MCK gene ...