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Statistical genetics is a scientific field concerned with the development and application of statistical methods for drawing inferences from genetic data. The term is most commonly used in the context of human genetics. Research in statistical genetics generally involves developing theory or methodology to support research in one of three ...
Genetic variability is either the presence of, or the generation of, genetic differences. It is defined as "the formation of individuals differing in genotype , or the presence of genotypically different individuals, in contrast to environmentally induced differences which, as a rule, cause only temporary, nonheritable changes of the phenotype ."
Ronald Fisher in 1913. Genetic variance is a concept outlined by the English biologist and statistician Ronald Fisher in his fundamental theorem of natural selection.In his 1930 book The Genetical Theory of Natural Selection, Fisher postulates that the rate of change of biological fitness can be calculated by the genetic variance of the fitness itself. [1]
Genetic variation can be identified at many levels. Identifying genetic variation is possible from observations of phenotypic variation in either quantitative traits (traits that vary continuously and are coded for by many genes, e.g., leg length in dogs) or discrete traits (traits that fall into discrete categories and are coded for by one or a few genes, e.g., white, pink, or red petal color ...
It is well established that the genetic diversity among human populations is low, [3] although the distribution of the genetic diversity was only roughly estimated. Early studies argued that 85–90% of the genetic variation is found within individuals residing in the same populations within continents (intra-continental populations) and only ...
Genetic drift can cause alleles to disappear from a population, and this lowers genetic diversity. In small populations, low genetic diversity can increase rates of inbreeding, which can result in inbreeding depression , in which a population made up of genetically similar individuals loses fitness .
Nucleotide diversity is a measure of genetic variation. It is usually associated with other statistical measures of population diversity, and is similar to expected heterozygosity . This statistic may be used to monitor diversity within or between ecological populations, to examine the genetic variation in crops and related species, [ 3 ] or to ...
The fact that levels of genetic diversity vary much less than population sizes do is known as the "paradox of variation". [66] While high levels of genetic diversity were one of the original arguments in favor of neutral theory, the paradox of variation has been one of the strongest arguments against neutral theory.