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Synergy is an interaction or cooperation giving rise to a whole that is greater than the simple sum of its parts (i.e., a non-linear addition of force, energy, or effect). [1] The term synergy comes from the Attic Greek word συνεργία synergia [2] from synergos, συνεργός, meaning "working together".
Additive effect can be used to detect synergy as it can be considered as the baseline effect in methods determining whether drugs have synergistic effect. Synergistic effect is similar to additive effect, having a combination effect greater than additive effect. It can produce an effect of 2+2 > 4 when two drugs are used together.
In the synergistic response, the applied antibiotics work together to produce an effect more potent than if each antibiotic were applied singly. [1] Compare to the additive effect , where the potency of an antibiotic combination is roughly equal to the combined potencies of each antibiotic singly, and antagonistic effect, where the potency of ...
A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs. Interactions may occur by simultaneous targeting of receptors , directly or indirectly. For example, both Zolpidem and alcohol affect GABA A receptors , and their simultaneous consumption results in the overstimulation of the receptor, which can ...
Cumulative effects to the environment are the result of multiple activities whose individual direct impacts may be relatively minor but in combination with others result are significant environmental effects. The multiple impacts of different activities may have an additive, synergistic or antagonistic effect on one another and with natural ...
The damaging effects of diesel fuel pollution go beyond a synergistic role in asthma development. Exposure to a combination of microscopic diesel fuel particles among people with high blood cholesterol (i.e., low-density lipoprotein , LDL or "bad cholesterol") increases the risk for both heart attack and stroke above levels found among those ...
The captodative effect is the stabilization of radicals by a synergistic effect of an electron-withdrawing substituent and an electron-donating substituent. [ 2 ] [ 3 ] The name originates as the electron-withdrawing group (EWG) is sometimes called the "captor" group, whilst the electron-donating group (EDG) is the "dative" substituent. [ 3 ]
a substance that enhances the effect of another substance, such as a drug (see Synergy § Biological sciences) something relating to the theological position of synergism See also