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Desvenlafaxine is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar. [18]
The half-life of venlafaxine is about 5 hours, and with once-daily dosing, steady-state concentration is achieved after about 3 days, though its active metabolite desvenlafaxine lasts longer. [59] The half-life of desvenlafaxine is about 11 hours, and steady-state concentrations are achieved after 4 to 5 days. [ 58 ]
Colonoscopy (/ ˌ k ɒ l ə ˈ n ɒ s k ə p i /) or coloscopy (/ k ə ˈ l ɒ s k ə p i /) [1] is a medical procedure involving the endoscopic examination of the large bowel (colon) and the distal portion of the small bowel.
Therapeutic endoscopy is the medical term for an endoscopic procedure during which treatment is carried out via the endoscope. This contrasts with diagnostic endoscopy , where the aim of the procedure is purely to visualize a part of the gastrointestinal , respiratory or urinary tract in order to aid diagnosis .
Whole bowel irrigation is sometimes used prior to colonoscopy, bowel surgery, other abdominal/pelvic surgery, or a barium enema examination, to cleanse the intestines, enhancing visibility of the intestines' inner surfaces, preventing complications from occurring as a result of spillage of bowel contents into the abdominal cavity, and potentially providing other benefits depending on the type ...
This article was reviewed by Daniel Z. Lieberman, MD. If you’ve been diagnosed with major depressive disorder, seasonal affective depression or any other type of depression, your healthcare ...
Although described as SNRIs, duloxetine (Cymbalta), venlafaxine (Effexor), and desvenlafaxine (Pristiq) are in fact relatively selective as serotonin reuptake inhibitors (SRIs). [201] They are about at least 10-fold selective for inhibition of serotonin reuptake over norepinephrine reuptake. [ 201 ]
Colorectal surgery is a field in medicine dealing with disorders of the rectum, anus, and colon. [1] The field is also known as proctology, but this term is now used infrequently within medicine and is most often employed to identify practices relating to the anus and rectum in particular.