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Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3' end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5' end of the guide strand. They bind the mature miRNA and orient it for ...
This microRNA database and microRNA targets databases is a compilation of databases and web portals and servers used for microRNAs and their targets. MicroRNAs (miRNAs) represent an important class of small non-coding RNAs (ncRNAs) that regulate gene expression by targeting messenger RNAs.
MicroRNA sequencing (miRNA-seq), a type of RNA-Seq, is the use of next-generation sequencing or massively parallel high-throughput DNA sequencing to sequence microRNAs, also called miRNAs. miRNA-seq differs from other forms of RNA-seq in that input material is often enriched for small RNAs. miRNA-seq allows researchers to examine tissue-specific expression patterns, disease associations, and ...
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n/a Ensembl ENSG00000284190 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 17: 59.84 – 59.84 Mb n/a PubMed search n/a Wikidata View/Edit Human microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly ...
Function Distribution Ref. Small nuclear RNA: snRNA: Splicing and other functions: Eukaryotes and archaea [3] Small nucleolar RNA: snoRNA: Nucleotide modification of RNAs: Eukaryotes and archaea [4] SmY RNA: SmY: mRNA trans-splicing: Nematodes [5] Small Cajal body-specific RNA: scaRNA: Type of snoRNA; Nucleotide modification of RNAs: Guide RNA ...
Many mammalian genomes encode four closely related miR-29 precursors that are transcribed in two transcriptional units. For example, human miR-29a and miR-29b-1 are processed from an intron of a long non-coding transcript pri-miRNA (lnc-pri-miRNA) LOC646329 from chromosome 7. miR-29b-2 (identical in sequence to miR-29b-1) and miR-29c are co-transcribed from chromosome 1.
MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-221 is an oncogenic microRNA. [1] It targets CD117, which then prevents cell migration and proliferation in endothelial cells. [2] [3] miR-221 is known as an anti angiogenic miRNA.