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The use of ultrasound to facilitate blood-brain barrier disruption has been tested in animal trials including primates. Research has been focused on using this tool for improving the treatment of glioblastoma, and studies have noted that microbubble-enhanced focused-ultrasound (MB-FUS) systems can be used for drug delivery as well as diagnostics.
[1] [2] Many existing cancer treatment strategies cause systemic toxicity or cannot penetrate tissue deep enough to reach the entire tumor; however, emerging ultrasound stimulated therapies could offer an alternative to these treatments with their increased efficiency, greater penetration depth, and reduced side effects. Sonodynamic therapy ...
Other uses of ultrasound for therapeutic benefit are at various stages in transitioning from research to clinical use and include: high-intensity focused ultrasound (HIFU), targeted ultrasound drug delivery, trans-dermal ultrasound drug delivery, ultrasound hemostasis, cancer therapy, and ultrasound assisted thrombolysis [2] [3] Ultrasound used ...
The Journal of Cancer is a peer-reviewed open access medical journal covering all areas of cancer research and oncology, published by Ivyspring International Publisher.The editors-in-chief are Yan-Gao Man (Bon Secours Cancer Institute) and Naoto T. Ueno (University of Texas M. D. Anderson Cancer Center).
Research and Reports in Endocrine Disorders † Research and Reports in Focused Ultrasound † Research and Reports in Forensic Medical Science; Research and Reports in Medicinal Chemistry † Research and Reports in Neonatology; Research and Reports in Nuclear Medicine † Research and Reports in Transdermal Drug Delivery †
Journal of Ultrasound in Medicine is a medical journal that covers aspects of medical ultrasound, mainly its direct application to patient care but also relevant basic science, and biological effects etc. The journal is published by Wiley. [1]
Contrast-enhanced ultrasound (CEUS) imaging has also been researched and shows similar sensitivity to MRI in detecting breast cancer across lesions of similar size. Additionally, the combined use of MRI and CEUS in lesions > 20 mm has been shown to optimize the diagnostic specificity and accuracy in breast cancer prediction. [43]
Ultrasound imaging deposits energy over a large area while therapeutic ultrasound focuses the energy on one target site. Focused ultrasound for intracrainial drug delivery is a non-invasive technique that uses high-frequency sound waves (focused ultrasound, or FUS) to disrupt tight junctions in the blood–brain barrier (BBB), allowing for increased passage of therapeutics into the brain.