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The effects of psychedelics on neuroplasticity appear to be dependent on serotonin 5-HT 2A receptor activation, as they are abolished in 5-HT 2A receptor knockout mice. [7] Non-hallucinogenic serotonin 5-HT 2A receptor agonists, like tabernanthalog and lisuride, have also been found to increase neuroplasticity, and to a magnitude comparable to ...
The first documented use of "nootropic" in reference to substances purported to increase cognitive functions was by Corneliu E. Giurgea in 1972. [ 5 ] [ 6 ] [ 7 ] When researching a new compound, Giurgea found a spectrum of effects that did not align with any psychotropic drug category, leading to his proposal of a new category and the concept ...
Drugs of abuse increase the VTA's ability to project dopamine to the rest of the reward circuit. [6] These structural changes only last 7–10 days, [ 7 ] however, indicating that the VTA cannot be the only part of the brain that is affected by drug use, and changed during the development of addiction.
The hippocampus regulates memory function. Memory improvement is the act of enhancing one's memory. Factors motivating research on improving memory include conditions such as amnesia, age-related memory loss, people’s desire to enhance their memory, and the search to determine factors that impact memory and cognition.
A study finds that antidepressants don’t boost the feel-good brain chemical serotonin, as previously thought. Here’s what you need to know.
Psychedelic microdosing involves consuming sub-threshold doses of serotonergic psychedelic drugs like LSD and psilocybin to potentially enhance creativity, energy, emotional balance, problem-solving abilities, and to address anxiety, depression, [1] and addiction.
Two molecular mechanisms for synaptic plasticity involve the NMDA and AMPA glutamate receptors. Opening of NMDA channels (which relates to the level of cellular depolarization) leads to a rise in post-synaptic Ca 2+ concentration and this has been linked to long-term potentiation, LTP (as well as to protein kinase activation); strong depolarization of the post-synaptic cell completely ...
“The brain is the body's most important sexual organ, so one of the best ways to increase the intensity of your orgasm is to increase arousal—for example, by fantasizing and living out your ...