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Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. [1] Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size.
Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. [2] In population genetics, the genotype frequency is the frequency or proportion (i.e., 0 < f < 1) of genotypes in a population.
1. Introduce the reference of a SNP of interest, as an example: rs429358, in a database (dbSNP or other). 2. Find MAF/MinorAlleleCount link. MAF/MinorAlleleCount: C=0.1506/754 (1000 Genomes, where number of genomes sampled = N = 2504); [4] where C is the minor allele for that particular locus; 0.1506 is the frequency of the C allele (MAF), i.e. 15% within the 1000 Genomes database; and 754 is ...
In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
Consider a population of monoecious diploids, where each organism produces male and female gametes at equal frequency, and has two alleles at each gene locus. We assume that the population is so large that it can be treated as infinite. Organisms reproduce by random union of gametes (the "gene pool" population model).
The allele frequency spectrum can be written as the vector = (,,,,), where is the number of observed sites with derived allele frequency . In this example, the observed allele frequency spectrum is ( 4 , 2 , 1 , 0 , 1 ) {\displaystyle (4,2,1,0,1)} , due to four instances of a single observed derived allele at a particular SNP loci, two ...
The quantity pq is maximized when there is an equal frequency of each gene, when =. In the GSM, the rate of change Δ Q {\displaystyle \Delta Q} is proportional to the genetic variation. The mean population fitness W ¯ {\displaystyle {\overline {W}}} is a measure of the overall fitness of the population.
In genetics, a centimorgan (abbreviated cM) or map unit (m.u.) is a unit for measuring genetic linkage. It is defined as the distance between chromosome positions (also termed loci or markers) for which the expected average number of intervening chromosomal crossovers in a single generation is 0.01. It is often used to infer distance along a ...