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Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
Nevertheless, even the best 3D culture models fail to mimic an organ's cellular properties in many aspects, [6] including tissue-to-tissue interfaces (e.g., epithelium and vascular endothelium), spatiotemporal gradients of chemicals, and the mechanically active microenvironments (e.g. arteries' vasoconstriction and vasodilator responses to ...
Overall, microfluidic devices increase the control over the organ-specific microenvironment, which allows for more precise models. [ 7 ] Different technologies have been used to introduce microfluidic flows in intestine-on-a-chip devices, including peristaltic pumps , [ 10 ] syringe pumps , [ 11 ] pressure generators [ 12 ] and pumpless systems ...
Move over, Wordle and Connections—there's a new NYT word game in town! The New York Times' recent game, "Strands," is becoming more and more popular as another daily activity fans can find on ...
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Organ chips are devices containing hollow microvessels filled with cells simulating tissue and/or organs as a microfluidic system that can provide key chemical and electrical signal information. [48] This is distinct from an alternative use of the term microchip , which refers to small, electronic chips that are commonly used as an identifier ...
An example of a bio-MEMS device is this automated FISH microchip, which integrates a reagent multiplexer, a cell chamber with a thin-film heater layer, and a peristaltic pump. [ 1 ] Bio-MEMS is an abbreviation for biomedical (or biological) microelectromechanical systems .