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These chromosomes, carrying genetic information, align in the equator of the cell between the spindle poles at the metaphase plate, before being separated into each of the two daughter nuclei. This alignment marks the beginning of metaphase. [2] Metaphase accounts for approximately 4% of the cell cycle's duration. [citation needed]
The days in which a woman is most fertile can be calculated based on the date of the last menstrual period and the length of a typical menstrual cycle. [4] The few days surrounding ovulation (from approximately days 10 to 18 of a 28-day cycle), constitute the most fertile phase.
This interval includes the G 2 phase and metaphase (annotated as "Meta."). Further information: Karyotype G 2 phase , Gap 2 phase , or Growth 2 phase , is the third subphase of interphase in the cell cycle directly preceding mitosis .
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Chromosomes at various stages of mitosis.Karyograms are generally made by chromosomes in prometaphase or metaphase. During these phases, the two copies of each chromosome (connected at the centromere) will look as one unless the image resolution is high enough to distinguish the two.
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Schematic karyogram of the human chromosomes, showing their usual state in the G 0 and G 1 phase of the cell cycle. At top center it also shows the chromosome 3 pair in metaphase (annotated as "Meta."), which takes place after having undergone DNA synthesis which occurs in the S phase (annotated as S) of the cell cycle.
In addition to the centromere, one or more secondary constrictions can be observed in some chromosomes at metaphase. In humans they are usually associated with the short arm of an acrocentric chromosome, [ 1 ] such as in the chromosomes 13, 14, 15, 21, & 22.