Search results
Results from the WOW.Com Content Network
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
In humans, there are 29 known family members of the TNF receptor superfamily. [6] [7] Historically, the family members have been numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter. [2] Some newer additions to the TNF family remain unnumbered, however, such as the TNF receptor superfamily member ...
TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6] It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are cytokines, chemical messengers of the immune system. [7]
Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body.
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A.This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity.
The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term ...
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. [ 5 ] [ 6 ] BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived ...
21944 Ensembl ENSG00000239697 ENSMUSG00000097328 UniProt O43508 O54907 RefSeq (mRNA) NM_003809 NM_011614 RefSeq (protein) NP_003800 NP_035744 Location (UCSC) Chr 17: 7.55 – 7.56 Mb Chr 11: 69.58 – 69.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in ...