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Candesartan is an angiotensin receptor blocker used ... the metabolism of the drug is unusual as it is a cascading prodrug. Candesartan has good bioavailibility and ...
Candesartan cilexetil (TCV 116) is a benzimidazole which was developed at Takeda and is an ester carbonate prodrug. In vivo, it is rapidly converted to the much more potent corresponding 7-carboxylic acid, candesartan. In the interaction of candesartan with AT 1 receptor the carboxyl group of the benzimidazole ring plays an important role ...
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1] [2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted . [3] [4]
Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases. [25] Sacubitrilat inhibits the enzyme neprilysin, [26] a neutral endopeptidase that degrades vasoactive peptides, including natriuretic peptides, bradykinin, and adrenomedullin. Thus, sacubitril increases the levels of these peptides, causing ...
1559 72303 Ensembl ENSG00000138109 ENSMUSG00000067231 UniProt P11712 n/a RefSeq (mRNA) NM_000771 NM_028191 RefSeq (protein) NP_000762 n/a Location (UCSC) Chr 10: 94.94 – 94.99 Mb Chr 19: 39.05 – 39.08 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by ...
A neurotransmitter prodrug, or neurotransmitter precursor, is a drug that acts as a prodrug of a neurotransmitter. A variety of neurotransmitter prodrugs have been developed and used in medicine .
It is available as a prodrug, olmesartan medoxomil. Common side effects include dizziness, headaches, diarrhea, and back pain. [2] Serious side effects may include kidney problems, low blood pressure, and angioedema. [2] Use in pregnancy may harm the fetus and use when breastfeeding is not recommended. [3]
Azilsartan, sold under the brand name Edarbi among others, is used for the treatment of hypertension. [2] [3] [4] It is used as the prodrug azilsartan medoxomil, is an angiotensin II receptor antagonist, [5] and was developed by Takeda.