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The Radial Unit Hypothesis (RUH) is a conceptual theory of cerebral cortex development, first described by Pasko Rakic. It states that the cerebral cortex develops during embryogenesis as an array of interacting cortical columns , or 'radial units', each of which originates from a transient stem cell layer called the ventricular zone , which ...
The marginal zone, along with the cortical zone, make up the 6 layers that form the cortex. This zone is the predecessor for layer I of the cortex. Astrocytes form an outer limiting membrane to interact with the pia. In humans it has been found that the cells here also form a subpial layer. [1]
In 1891 Santiago Ramón y Cajal described slender horizontal bipolar cells he had found in an histological preparation of the developing marginal zone of lagomorphs. [28] These cells were then considered by Gustaf Retzius as homologous to the ones he had found in the marginal zone of human fetuses around mid-gestation in 1893 and 1894. He ...
The development of the nervous system in humans, or neural development, or neurodevelopment involves the studies of embryology, developmental biology, and neuroscience. These describe the cellular and molecular mechanisms by which the complex nervous system forms in humans, develops during prenatal development , and continues to develop ...
Epigenetics of human development is the study of how epigenetics (hertiable characteristics that do not involve changes in DNA sequence) effects human development. Development before birth, including gametogenesis , embryogenesis , and fetal development , is the process of body development from the gametes are formed to eventually combine into ...
During the midfetal period of fetal development the subplate zone is the largest zone in the developing telencephalon. It serves as a waiting compartment for growing cortical afferents ; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other ...
This hypothesis suggested that poor growth during the fetal and infant stages can cause a development of type 2 diabetes later in life. Hales and Barker suggested that this poor growth was due to maternal malnutrition which leads to low birth weight.
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph ...