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Treatment was based on the humour theory of four bodily fluids (black and yellow bile, blood, and phlegm). According to the patient's humour, treatment consisted of diet, blood-letting, and/or laxatives. Celsus (c. 25 BC – 50 AD) translated carcinos into cancer, the Latin word for crab or crayfish.
Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
1900 – Swedish Dr. Stenbeck cures a skin cancer with small doses of radiation [4]; 1920s – Dr. William B. Coley's immunotherapy treatment, regressed tumors in hundreds of cases, the success of Coley's Toxins attracted heavy resistance from his rival and supervisor, Dr. James Ewing, who was an ardent supporter of radiation therapy for cancer.
1761 – A case of breast cancer cured after ulcerating and getting infected is reported by Lambergen [3] 1796 – First demonstration of smallpox vaccination (Edward Jenner) 1808–1813 – First experimental demonstration of the germ theory of disease by Agostino Bassi though he does not formally propose the theory until 1844
The theory about the monoclonal origin of cancer states that, in general, neoplasms arise from a single cell of origin. [1] While it is possible that certain carcinogens may mutate more than one cell at once, the tumor mass usually represents progeny of a single cell, or very few cells. [ 1 ]
The hallmarks of cancer were originally six biological capabilities acquired during the multistep development of human tumors and have since been increased to eight capabilities and two enabling capabilities. The idea was coined by Douglas Hanahan and Robert Weinberg in their paper "The Hallmarks of Cancer" published January 2000 in Cell. [1]
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Another evolutionary theory puts the roots of cancer back to the origin of the eukaryote (nucleated) cell by massive horizontal gene transfer, when the genomes of infecting viruses were cleaved (and thereby attenuated) by the host, but their fragments integrated into the host genome as immune protection. Cancer thus originates when a rare ...