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  2. Armodafinil - Wikipedia

    en.wikipedia.org/wiki/Armodafinil

    A Cephalon-founded study in which patients were administered modafinil, methylphenidate, and a placebo found that modafinil produces "psychoactive and euphoric effects and feelings consistent with [methylphenidate]." [12] Like modafinil, armodafinil is an inhibitor and/or inducer of certain cytochrome P450 enzymes.

  3. List of modafinil analogues and derivatives - Wikipedia

    en.wikipedia.org/wiki/List_of_modafinil...

    [3] [2] [4] The modafinil analogues are of interest in the potential treatment of a condition involving the misuse of stimulant drugs (psychostimulant use disorder or PSUD), as drugs that help increase motivation (pro-motivational agents) to treat motivational disorders, [4] [5] [6] and for treatment of neurodegenerative diseases such as ...

  4. Modafinil - Wikipedia

    en.wikipedia.org/wiki/Modafinil

    In a later large phase 3 clinical trial of modafinil for adult ADHD, modafinil was not effective in improving symptoms, there was also a high rate of side effects (86%) and discontinuation (47%). [248] The poor tolerability of modafinil in this study was possibly due to the use of high doses (210–510 mg/d). [248]

  5. Management of attention deficit hyperactivity disorder

    en.wikipedia.org/wiki/Management_of_attention...

    Attention deficit hyperactivity disorder management options are evidence-based practices with established treatment efficacy for ADHD.Approaches that have been evaluated in the management of ADHD symptoms include FDA-approved pharmacologic treatment and other pharmaceutical agents, psychological or behavioral approaches, combined pharmacological and behavioral approaches, cognitive training ...

  6. JJC8-016 - Wikipedia

    en.wikipedia.org/wiki/JJC8-016

    Subsequently, more selective modafinil-derived DAT blockers, like JJC8-088 and JJC8-091, were developed. [1] [9] JJC8-088 has ~90-fold higher affinity for the DAT than JJC8-016 and ~2-fold lower affinity for the hERG. [9] Newer related modafinil analogues and DRIs with further reduced affinity for the hERG were also subsequently developed. [11]

  7. Flmodafinil - Wikipedia

    en.wikipedia.org/wiki/Flmodafinil

    Flmodafinil (developmental code names CRL-40,940, NLS-4, JBG01-41), also known as bisfluoromodafinil and lauflumide, is a wakefulness-promoting agent related to modafinil which has been developed for treatment of a variety of different medical conditions.

  8. Eugeroic - Wikipedia

    en.wikipedia.org/wiki/Eugeroic

    Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil, and adrafinil, among others. [9] They are medically indicated for the treatment of certain sleep disorders , including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).

  9. Guanfacine - Wikipedia

    en.wikipedia.org/wiki/Guanfacine

    Guanfacine was first described by 1974 [12] and was approved for medical use in the United States in 1986. [10] It is available as a generic medication. [10] In 2022, it was the 275th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.

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