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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Most men and women know at least vaguely what Viagra does, but not everyone knows how it does it. ... This is thanks to an enzyme called phosphodiesterase type 5 (PDE5). Viagra inhibits PDE5 and ...
A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. ... Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, ...
Sildenafil (marketed as Viagra) was the first PDE5 inhibitor on the market. Originally created as a treatment for high blood pressure in 1989, it was found to have a secondary use as an effective PDE5 inhibitor, enabling men who use it to gain stronger erections after arousal. The FDA approved Viagra on March 27, 1998. [20]
Viagra and Other PDE5 Inhibitors. Viagra isn’t the only PDE5 inhibitor on the market. In fact, the FDA has approved three other PDE5 inhibitors to help treat the symptoms of ED:
What Does Viagra Do? Viagra works by improving blood flow to your privates. The active ingredient, Sildenafil, is a PDE5 inhibitor that helps blood vessels relax.
The PDE5 enzyme has a molecular mass of 200 kDa and its active state is a homodimer. [21] PDE5 consists of monomers and each contains two major functional domains: the regulatory domain (R domain) which is located in the N-terminal portion of the protein and the catalytic domain (C domain) located in the more C-terminal portion of the protein ...
PDE5 inhibitors increase blood flow to your privates, ... Viagra can cause side effects, interact with certain medications and be a bad option for people with certain health conditions. Speak ...
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