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α 1-antitrypsin: 52 kDa: Also known as serum trypsin inhibitor Lima beans: 8–10 kDa 2.2 times weight A mixture of six different inhibitors Bovine pancreas and lung: Aprotinin: 6.5 kDa 2.5 times weight Also known as BPTI (basic pancreatic trypsin inhibitor) and Kunitz inhibitor. Best-known pancreatic inhibitor. Inhibits several different ...
Alpha-1 antitrypsin or α 1-antitrypsin (A1AT, α 1 AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene . A protease inhibitor , it is also known as alpha 1 –proteinase inhibitor ( A1PI ) or alpha 1 -antiproteinase ( A1AP ) because it inhibits various proteases (not just trypsin ). [ 5 ]
Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. [1] Onset of lung problems is typically between 20 and 50 years of age. [ 1 ] This may result in shortness of breath , wheezing , or an increased risk of lung infections .
Aprotinin is a monomeric (single-chain) globular polypeptide derived from bovine lung tissue. It has a molecular weight of 6512 Da and consists of 16 different amino acid types arranged in a chain 58 residues long [4] [5] that folds into a stable, compact tertiary structure of the 'small SS-rich" type, containing 3 disulfides, a twisted β-hairpin and a C-terminal α-helix.
The identification of the S and Z mutations [21] [22] responsible for the genetic deficiency and the subsequent sequence alignments of alpha1-antitrypsin and antithrombin in 1982 led to the recognition of the close homologies of the active sites of the two proteins, [23] [24] centred on a methionine [25] in alpha1-antitrypsin as an inhibitor of ...
20714 Ensembl ENSG00000196136 ENSMUSG00000058207 UniProt P01011 P07759 RefSeq (mRNA) NM_001085 NM_011458 RefSeq (protein) NP_001076 NP_035588 Location (UCSC) Chr 14: 94.61 – 94.62 Mb Chr 12: 104.3 – 104.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alpha 1-antichymotrypsin (symbol α 1 AC, A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin ...
Tracy (1990 – 1997) was a transgenically modified sheep created by scientists at Scotland's Roslin Institute to produce the human protein alpha 1-antitrypsin, a substance regarded in the 1990s as a potential pharmaceutical for the treatments of cystic fibrosis and emphysema. [1]
Alpha 2-antiplasmin (or α 2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. [5] Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins.