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Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin, an anticoagulant. HIT predisposes to thrombosis (the abnormal formation of blood clots inside a blood vessel ).
Therefore, it has a predictable antithrombotic response. There is no risk for heparin-induced thrombocytopenia or heparin-induced thrombosis-thrombocytopenia syndrome. [2] It does not require a binding cofactor such as antithrombin and does not activate platelets. [6] [9] These characteristics make bivalirudin an ideal alternative to heparin.
Argatroban (as well as the hirudins) is used for heparin-induced thrombocytopenia, a relatively infrequent yet serious complication of heparin treatment that requires anticoagulation (as it increases both arterial and venous thrombosis risk) but not with the causative agent, heparin. [1]
alternative to heparin in those developing heparin-induced thrombocytopenia [42] [25] desirudin: anticoagulant inhibits prothombin injection used with hip replacement [42] [25] Eptifibatide: antiplatelet [42] tirofiban: antiplatelet [42] ticlopidine: antiplatelet [42] pentoxifylline: antiplatelet [42] cilostazol: antiplatelet [42] rivaroxaban ...
Heparin mimicking polymers can be synthesized through a variety of mechanisms. To begin, monomers can be either synthesized or purchased from avenues such as Sigma Aldrich. The monomers are the basic subunits of the polymer and can be designed to incorporate specific functional groups, e.g. sugars , urea , which can enhance the biocompatibility ...
Another potentially severe complication associated with heparin use is called heparin-induced thrombocytopenia (HIT). [57] There are two distinct types: HIT 1) immune-mediated and 2) non-immune-mediated. [57] Immune-mediated HIT most commonly arises five to ten days after exposure to heparin. [58]
Fondaparinux is a synthetic pentasaccharide factor Xa inhibitor. Fondaparinux binds antithrombin and accelerates its inhibition of factor Xa.. Apart from the O-methyl group at the reducing end of the molecule, the identity and sequence of the five monomeric sugar units contained in fondaparinux is identical to a sequence of five monomeric sugar units that can be isolated after either chemical ...
Protamine sulfate is a medication that is used to reverse the effects of heparin. [3] It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery. [3] [4] It is given by injection into a vein. [3] The onset of effects is typically within five ...