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Helenalin, or (-)-4-Hydroxy-4a,8-dimethyl-3,3a,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione, is a toxic sesquiterpene lactone which can be found in several plants such as Arnica montana and Arnica chamissonis Helenalin is responsible for the toxicity of the Arnica spp.
Arnica montana. Arnica montana is a flowering plant about 18–60 cm (7.1–23.6 in) tall aromatic fragrant, herbaceous perennial. Its basal green ovate leaves with rounded tips are bright coloured and level to the ground. In addition, they are somewhat downy on their upper surface, veined and aggregated in rosettes.
Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or lethal." [3]
Less-common side effects can include excess air or gas in your stomach, burping, heartburn, indigestion, fast heartbeat, low blood sugar, low energy and fatigue, or even gallstones, Dr. Comite says.
Arnica montana: Arnica: Used as an anti-inflammatory [23] and for osteoarthritis. [24] The US Food and Drug Administration has classified Arnica montana as an unsafe herb because of its toxicity. [25] It should not be taken orally or applied to broken skin where absorption can occur. [25] Astragalus propinquus: Astragalus: Long used in ...
2. Acute Kidney Injury. Some reports in a review supported by Novo Nordisk suggested that semaglutide may decrease the risk of kidney disease over the long term. But there were also a few reports ...
Arnica / ˈ ɑːr n ɪ k ə / is a genus of perennial, herbaceous plants in the sunflower family ().The genus name Arnica may be derived from the Greek arni, "lamb", in reference to the plants' soft, hairy leaves.
Arnica montana: mountain arnica, mountain tobacco, wolf's bane, leopard's bane Asteraceae: It contains the toxin helenalin, which can be poisonous if large amounts of the plant are eaten or small amounts of concentrated Arnica are used.
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