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In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment. The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation. [2] According to some sources, there are two conditions included on a spectrum of this same disease process: Stevens–Johnson syndrome (SJS)
The condition varies from a mild, self-limited rash (E. multiforme minor) [4] to a severe, life-threatening form known as erythema multiforme major (or erythema multiforme majus) that also involves mucous membranes. [5] Consensus classification: [6] Erythema multiforme minor—typical targets or raised, edematous papules distributed acrally
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction. [1] Together with toxic epidermal necrolysis (TEN) and Stevens–Johnson/toxic epidermal necrolysis (SJS/TEN) overlap, they are considered febrile mucocutaneous drug reactions and probably part of the same spectrum of disease, with SJS being less severe.
Erythema multiforme (EM) is usually a reaction of the skin and mucous membranes that occurs suddenly. [1] It appears as a symmetrical rash and may include the mucous membrane lesions. This means that the body is sensitive to something that causes the skin and mucous membranes to react. The more common mild form is refer to as EM minor.
Erythema annulare centrifugum (deep gyrate erythema, erythema perstans, palpable migrating erythema, superficial gyrate erythema) Erythema gyratum repens (Gammel's disease) Erythema migrans (erythema chronicum migrans) Erythema multiforme; Erythema multiforme minor (herpes simplex-associated erythema multiforme) Erythema palmare; Generalized ...
Erythema multiforme, Toxic epidermal necrolysis Apoptotic and necrotic cells, absence of acantholytic cells A Tzanck smear may be a rapid test to distinguish toxic epidermal necrolysis from SSSS III. Genodermatoses: Hailey-Hailey disease: Acantholytic cells without direct immunofluorescence positivity
Erythema multiforme (EM) is generally considered a separate condition. [6] Treatment typically takes place in hospital such as in a burn unit or intensive care unit. [3] [7] Efforts include stopping the cause, pain medication, and antihistamines. [3] [4] Antibiotics, intravenous immunoglobulins, and corticosteroids may also be used.
Hives, also known as urticaria, is a kind of skin rash with red and/or flesh-colored, raised, itchy bumps. [1] Hives may burn or sting. [2] The patches of rash may appear on different body parts, [2] with variable duration from minutes to days, and do not leave any long-lasting skin change. [2]