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P11-4 is a self-assembling β-peptide. It builds a 3-D bio-matrix with binding sites for Calcium-ions serving as nucleation point for hydroxyapatite (tooth mineral) formation. The high affinity to tooth mineral is based on matching distances of Ca-ion binding sites on P11-4 and Ca spacing in the crystal lattice of hydroxyapatite.
Hydroxyapatite is widely used within dentistry and oral and maxillofacial surgery, due to its chemical similarity to hard tissue. [34] In the future, there are possibilities for using nano-hydroxyapatite for tissue engineering and repair. The main and most advantageous feature of nano-hydroxyapatite is its biocompatibility. [35]
In 1980, the Japanese company, Sangi Co., Ltd., launched APADENT, the world's first remineralizing toothpaste to use a nano-form of hydroxyapatite, the main component of tooth enamel, rather than fluoride, to remineralize areas of mineral loss below the surface of tooth enamel (incipient caries lesions).
A 1930s poster from the Work Projects Administration promoting oral hygiene. Tooth decay is the most common global disease. [14] Over 80% of cavities occur inside fissures in teeth where brushing cannot reach food left trapped after eating and saliva and fluoride have no access to neutralize acid and remineralize demineralized teeth, unlike easy-to-clean parts of the tooth, where fewer ...
In its pure form, as manufactured for toothpaste, it is an odorless, tasteless, white, gelatinous substance, which is chemically inert. One of the primary industrial methods to acquire hydrated silica is through a sol-gel process. [7] Hydrated silicas can be categorized into three main categories based on differences in crystallinity: [6]
Promise: [32] launched by Balsara hygiene in 1978 in India, the brand's tagline was "The unique toothpaste with time-tested clove oil." [38] P/S: a Vietnamese brand of toothpaste and toothbrush. However, in 2012, they made 3 actions called "P/S 123". Rembrandt toothpaste: a brand of toothpaste that has built its brand on the promise of whitening.
A 2007 Australian review concluded that water fluoridation is the most effective and socially the most equitable way to expose entire communities to fluoride's cavity-prevention effects. [11] A 2002 U.S. review estimated that sealants decreased cavities by about 60% overall, compared to about 18–50% for fluoride. [102]
The Macleans company scored a major takeover after Woolworths stocked it in the early 1930s (as the company only sold Colgate toothpaste previously). In 1938, Macleans was purchased by Beecham Group. [5] In 1987, GlaxoSmithKline introduced an antibacterial agent into the Macleans toothpaste, being the first to do so.
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