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Buspirone. Buspirone, sold under the brand name Buspar, among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder (GAD). [10][11] It is a serotonin 5-HT 1A receptor partial agonist, increasing action at serotonin receptors in the brain. [3]
Azapirones have shown benefit in general anxiety [14] and augmenting SSRIs in social anxiety [15] and depression. [16] Evidence is not clear for panic disorder [17] and functional gastrointestinal disorders. [18] Tandospirone has also been used to augment antipsychotics in Japan as it improves cognitive and negative symptoms of schizophrenia. [19]
5-HT 1A receptor agonists like buspirone [18] and flesinoxan [19] show efficacy in relieving anxiety [20] and depression. [21] Buspirone and tandospirone are currently approved for these indications in different parts of the world.
In Wikidata. Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into ...
SSRIs are beneficial in both acute response and long-term maintenance treatment for both depression and anxiety disorder. [16] SSRIs can increase anxiety initially due to negative feedback through the serotonergic autoreceptors; for this reason a concurrent benzodiazepine can be used until the anxiolytic effect of the SSRI occurs. [18]
Tandospirone, sold under the brand name Sediel, is an anxiolytic and antidepressant medication used in Japan and China, where it is marketed by Dainippon Sumitomo Pharma. It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone.
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