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A nucleic acid sequence is the order of nucleotides within a DNA (GACT) or RNA (GACU) molecule that is determined by a series of letters. Sequences are presented from the 5' to 3' end and determine the covalent structure of the entire molecule. Sequences can be complementary to another sequence in that the base on each position is complementary ...
DNA and RNA codon tables. A codon table can be used to translate a genetic code into a sequence of amino acids. [ 1][ 2] The standard genetic code is traditionally represented as an RNA codon table, because when proteins are made in a cell by ribosomes, it is messenger RNA (mRNA) that directs protein synthesis. [ 2][ 3] The mRNA sequence is ...
Coding region. The coding region of a gene, also known as the coding sequence ( CDS ), is the portion of a gene's DNA or RNA that codes for a protein. [ 1] Studying the length, composition, regulation, splicing, structures, and functions of coding regions compared to non-coding regions over different species and time periods can provide a ...
The sequence of nucleobases on a nucleic acid strand is translated by cell machinery into a sequence of amino acids making up a protein strand. Each group of three bases, called a codon, corresponds to a single amino acid, and there is a specific genetic code by which each possible combination of three bases corresponds to a specific amino acid.
Directionality (molecular biology) A furanose (sugar-ring) molecule with carbon atoms labeled using standard notation. The 5′ is upstream; the 3′ is downstream. DNA and RNA are synthesized in the 5′-to-3′ direction. Directionality, in molecular biology and biochemistry, is the end-to-end chemical orientation of a single strand of ...
The main nucleic acid helix structures (A-, B- and Z-form) Nucleic acid secondary structure is generally divided into helices (contiguous base pairs), and various kinds of loops (unpaired nucleotides surrounded by helices). Frequently these elements, or combinations of them, are further classified into additional categories including, for ...
Nucleic acid tertiary structure is the three-dimensional shape of a nucleic acid polymer. [ 1] RNA and DNA molecules are capable of diverse functions ranging from molecular recognition to catalysis. Such functions require a precise three-dimensional structure. While such structures are diverse and seemingly complex, they are composed of ...
R-loop. An R-loop is a three-stranded nucleic acid structure, composed of a DNA: RNA hybrid and the associated non-template single-stranded DNA. R-loops may be formed in a variety of circumstances and may be tolerated or cleared by cellular components. The term "R-loop" was given to reflect the similarity of these structures to D-loops; the "R ...