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Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. [1] [2] Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, [3] [4] [5] all of which can cause the full spectrum of disease. [1]
Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. It is frequently asymptomatic; if symptoms appear, they typically begin 3 to 14 days after infection.
There is a dengue vaccine for children aged 9 to sixteen if they have confirmation of a previous infection, or live in an area where dengue is common. Vaccines are recommended for U.S. territories ...
[51] This live-attenuated vaccine, developed by Takeda is similar to the Dengvaxia vaccine in the fact that it contains a weakened version of the four variants of dengue virus. The difference between the two vaccines is the TAK-003 vaccine can be administered without a prior dengue infection and it also induces cellular immunity against dengue ...
Reported cases of dengue in the Americas nearly tripled to a record high of over 12.6 million this year, including 21,000 severe cases and over 7,700 deaths, the Pan American Health Organization ...
The dengue virus causes symptoms including fever, headache, pain behind the eyes, muscle and joint pain, rash and bleeding. Severe cases can involve organ impairment, shock and severe bleeding.
Dengue is a Flaviviridae virus, with five genetic types. [8] [9] Here is the virus drawn as a 3-dimensional model of the envelope protein. [10]Dengue is in the same family as other well known viruses carried by mosquitoes that cause tropical diseases, such as yellow fever, West Nile, and Zika virus.
The dengue virus genome (genetic material) contains about 11,000 nucleotide bases, which code for the three different types of protein molecules (C, prM and E) that form the virus particle and seven other types of protein molecules (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5) that are found in infected host cells only and are required for ...