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Cisplatin is a chemical compound with formula cis-[Pt(NH 3) 2 Cl 2]. It is a coordination complex of platinum that is used as a chemotherapy medication used to treat a number of cancers . [ 3 ] These include testicular cancer , ovarian cancer , cervical cancer , bladder cancer , head and neck cancer , esophageal cancer , lung cancer ...
cisplatin, etoposide, bleomycin: non-seminomatous germ cell tumors PEI cisplatin, etoposide, ifosfamide: small-cell lung carcinoma platin + taxane [5] cisplatin/carboplatin, paclitaxel/docetaxel: ovarian cancer: POMP 6-mercaptopurine (Purinethol), vincristine (Oncovin), methotrexate, and prednisone: acute adult leukemia [6] ProMACE-MOPP
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme, which is an enzyme that aids in relaxing negative or positive supercoils in DNA. Topoisomerase II normally will form a double-stranded break in one DNA double-strand, allow another to pass through, and re-ligate the broken strands.
[6]: 55–59 [7]: 17–18 [5] Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. [6]: 55–59 It is also given for cancers with a high risk of micrometastatic disease. [8]: 42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). It can be used ...
Etoposide, a semi-synthetic derivative of epipodophyllotoxin is commonly used to study this apoptotic mechanism and include: Etoposide; Teniposide; Both etoposide and teniposide are naturally occurring semi-synthetic derivatives of podophyllotoxins and are important anti-cancer drugs that function to inhibit TopII activity. [67]
Tegafur/gimeracil/oteracil, sold under the brand name Teysuno among others is a fixed-dose combination medication used for the treatment of advanced gastric cancer when used in combination with cisplatin, [3] and also for the treatment of head and neck cancer, colorectal cancer, non–small-cell lung, breast, pancreatic, and biliary tract cancers.
Etoposide, an epipodophyllotoxin topoisomerase inhibitor; Solu-Medrol - Methylprednisolone, which is a glucocorticoid that can lyse lymphocytes; High-dose Ara-C - cytarabine; Platinol - Cisplatin, a platinum-based antineoplastic agent, also an alkylating antineoplastic agent.
Etoposide- a topoisomerase inhibitor from the epipodophyllotoxin group; Procarbazine - an alkylating antineoplastic agent; Prednisone or prednisolone - a glucocorticoid hormone that has the ability to cause apoptosis and lysis of lymphocytes, either normal or malignant; Bleomycin - an antitumor antibiotic