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106633 Ensembl ENSG00000187535 ENSMUSG00000024169 UniProt Q96RY7 E9PY46 RefSeq (mRNA) NM_014714 NM_134126 RefSeq (protein) NP_055529 NP_598887 Location (UCSC) Chr 16: 1.51 – 1.61 Mb Chr 17: 25.24 – 25.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse IFT140, Intraflagellar transport 140 homolog, is a protein that in humans is encoded by the IFT140 gene. The gene product forms a ...
The olfactory mucosa is the neuroepithelial mucosa [1] lining the roof and upper parts of the septum and lateral wall of the nasal cavity [1] [2] which contains bipolar neurons of the primary receptor neurons of the olfactory pathway, as well as supporting cells.
Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [ 6 ] In 2012 a mutation was found to be responsible for a novel form of ciliopathy and anosmia in humans capable of remedy in mice by adenoviral mediated gene therapy .
Anosmia may very occasionally be an early sign of a degenerative brain disease such as Parkinson's disease and Alzheimer's disease. [22] Another specific cause of permanent loss could be from damage to olfactory receptor neurons because of use of certain types of nasal spray; i.e., those that cause vasoconstriction of the nasal microcirculation ...
Neurologists have observed that olfactory dysfunction is a cardinal feature of several neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Most of these patients are unaware of an olfactory deficit until after testing where 85% to 90% of early-stage patients showed decreased activity in central odor processing ...
The olfactory nerve zone is composed of preterminals and terminals of the olfactory nerve and is where the olfactory receptor cells make synapses on their targets. [2] The non-olfactory nerve zone is composed of the dendritic processes of intrinsic neurons and is where dendrodendritic interactions between intrinsic neurons occur. [2]
Tornwaldt's disease is a rare benign disorder caused by persistent notochord remnants. [3] This disease almost remains asymptomatic. [citation needed] At about the 10th week of embryonic development, the pharyngeal pouch forms by adhesion of the pharyngeal ectoderm to the cranial end of the notochord.
Olfactory glands, also known as Bowman's glands, are a type of nasal gland situated in the part of the olfactory mucosa beneath the olfactory epithelium, that is the lamina propria, a connective tissue also containing fibroblasts, blood vessels and bundles of fine axons from the olfactory neurons.