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A dog with degenerative myelopathy often stands with its legs close together and may not correct an unusual foot position due to a lack of conscious proprioception. Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis (ALS).
Down syndrome or Down's syndrome, [12] also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. [3] It is usually associated with developmental delays, mild to moderate intellectual disability , and characteristic physical features.
Spinal and bulbar muscular atrophy (SBMA), popularly known as Kennedy's disease, is a rare, adult-onset, X-linked recessive lower motor neuron disease caused by trinucleotide CAG repeat expansions in exon 1 of the androgen receptor (AR) gene, which results in both loss of AR function and toxic gain of function.
Wet lung syndrome in newborn; WHIM syndrome; White dog shaker syndrome; White dot syndromes; White spot syndrome; White-nose syndrome; Wiedemann-Steiner syndrome; Wiedemann–Rautenstrauch syndrome; Wildervanck syndrome; Williams syndrome; Williams–Campbell syndrome; Wilson's temperature syndrome; Wilson–Mikity syndrome; Wilson–Turner ...
Exceptions to this finding are extremely rare cases in which boys with Klinefelter syndrome (44+xxy) also inherit an X-linked dominant condition and exhibit symptoms more similar to those of a female in terms of disease severity. The chance of passing on an X-linked dominant disorder differs between men and women.
An anaphase lag of a chromosome 21 in a Down syndrome embryo leads to a fraction of euploid cells (2n cells), phenomenon described as "aneuploidy rescue". There is considerable variability in the fraction of cells with trisomy 21, both as a whole and tissue-by-tissue. This is the cause of 1–2% of the observed Down syndromes. [4]
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Despite similar symptoms and blood test results to Cushing's disease, evaluation of dogs with SARDS did not reveal any tumors in the pituitary or adrenal glands, [9] and recent work has indicated significant differences in the clinical and laboratory test parameters between the two diseases. [10]