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Anticonvulsant agents, such as phenytoin, are associated with common forms of gingival overgrowth. [2] It is caused by the increase of metabolites from the breakdown of anticonvulsants in the body. [3] It should also be noted that concurrent usage of different anticonvulsants in children has resulted in accumulative gingival enlargement. [2]
In the case of immunosuppression, tacrolimus is an available alternative which results in much less severe gingival overgrowth than cyclosporin, but is similarly as nephrotoxic. [19] The dihydropyridine derivative isradipidine can replace nifedipine for some uses of calcium channel blocking and does not induce gingival overgrowth. [20]
These are far less common than plaque-induced gingival lesions. [6] Non-plaque-induced gingival disease is an inflammation of the gingiva that does not result from dental plaque, but from other gingival diseases caused by bacterial, viral, fungal, or genetic sources. Although this gingival disease is less common than those which are plaque ...
Drug-related gingival hyperplasia is a cutaneous condition characterized by enlargement of the gums noted during the first year of drug treatment. [1] Although the mechanism of drug related gingival hyperplasia is not well understood, some risk factors for the condition include the duration of drug use and poor oral hygiene . [ 2 ]
Hereditary gingival fibromatosis (HGF), also known as idiopathic gingival hyperplasia, is a rare condition of gingival overgrowth. [1] HGF is characterized as a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of keratinized gingiva. It can cover teeth in various degrees, and can lead to aesthetic disfigurement. [2]
Dental plaque biofilm-induced gingivitis; Non-dental-plaque-induced gingival disease; Dental plaque biofilm-induced gingivitis is often referred to as "localized inflammation initiated by microbial biofilm accumulation on teeth,". [2] Non-dental-plaque-induced gingival diseases are the most uncommon bacterial infection of the gingiva.
Phenytoin has been associated with drug-induced gingival enlargement (overgrowth of the gums), probably due to above-mentioned folate deficiency; indeed, evidence from a randomized controlled trial suggests that folic acid supplementation can prevent gingival enlargement in children who take phenytoin. [37]
Peripheral giant-cell granuloma (PGCG) is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma and peripheral ossifying fibroma. These three diseases are ...